| month | day | visitor | score | home | score |
|---|
| November | 2, 2004 | Pistons | | Magic | |
| November | 3, 2004 | Nets | | Pistons | |
| November | 7, 2004 | Pistons | | Celtics | |
| November | 9, 2004 | Hawks | | Pistons | |
| November | 11, 2004 | Wizards | | Pistons | |
| November | 16, 2004 | Pistons | | Wizards | |
| November | 18, 2004 | Bucks | | Pistons | |
| November | 23, 2004 | Pistons | | Pacers | |
| November | 24, 2004 | Bobcats | | Pistons | |
| November | 25, 2004 | Pistons | | Grizzlies | |
| November | 26, 2004 | Pistons | | Celtics | |
| December | 2, 2004 | Pistons | | Nets | |
| December | 3, 2004 | Pistons | | Suns | |
| December | 7, 2004 | Bucks | | Pistons | |
| December | 8, 2004 | Pistons | | Bobcats | |
| December | 11, 2004 | Sonics | | Pistons | |
| December | 12, 2004 | Pistons | | Hawks | |
| December | 15, 2004 | Pistons | | 76ers | |
| December | 18, 2004 | Pistons | | Nuggets | |
| December | 19, 2004 | Pistons | | Jazz | |
| December | 24, 2004 | Pistons | | 76ers | |
| December | 25, 2004 | 76ers | | Pistons | |
| December | 29, 2004 | Warriors | | Pistons | |
| December | 31, 2004 | Bulls | | Pistons | |
| January | 3, 2005 | Wolves | | Pistons | |
| January | 9, 2005 | Pistons | | Bobcats | |
| January | 10, 2005 | Pacers | | Pistons | |
| January | 12, 2005 | Pistons | | Hawks | |
| January | 16, 2005 | Pistons | | Magic | |
| January | 17, 2005 | Jazz | | Pistons | |
| January | 18, 2005 | Kings | | Pistons | |
| January | 19, 2005 | Pistons | | Raptors | |
| January | 20, 2005 | Pistons | | Heat | |
| January | 22, 2005 | Magic | | Pistons | |
| January | 23, 2005 | Pistons | | Hornets | |
| January | 25, 2005 | Bucks | | Pistons | |
| January | 28, 2005 | Clippers | | Pistons | |
| January | 29, 2005 | Raptors | | Pistons | |
| January | 30, 2005 | Knicks | | Pistons | |
| February | 1, 2005 | Pistons | | Bulls | |
| February | 4, 2005 | Pistons | | Raptors | |
| February | 6, 2005 | Pistons | | Cavaliers | |
| February | 7, 2005 | Cavaliers | | Pistons | |
| February | 8, 2005 | Blazers | | Pistons | |
| February | 13, 2005 | Bobcats | | Pistons | |
| February | 15, 2005 | Hornets | | Pistons | |
| February | 17, 2005 | Spurs | | Pistons | |
| February | 18, 2005 | Pistons | | Lakers | |
| February | 20, 2005 | Pistons | | Heat | |
| February | 21, 2005 | Pistons | | Clippers | |
| February | 22, 2005 | Bulls | | Pistons | |
| February | 27, 2005 | Pistons | | Spurs | |
| February | 28, 2005 | Pistons | | Bulls | |
| March | 2, 2005 | Pistons | | Bobcats | |
| March | 5, 2005 | Pistons | | Rockets | |
| March | 8, 2005 | Suns | | Pistons | |
| March | 10, 2005 | Pistons | | Cavaliers | |
| March | 11, 2005 | Pistons | | Knicks | |
| March | 12, 2005 | Cavaliers | | Pistons | |
| March | 14, 2005 | Lakers | | Pistons | |
| March | 15, 2005 | Mavericks | | Pistons | |
| March | 22, 2005 | Pistons | | Bucks | |
| March | 23, 2005 | Grizzlies | | Pistons | |
| March | 27, 2005 | Pistons | | Knicks | |
| March | 29, 2005 | Pacers | | Pistons | |
| March | 31, 2005 | Pistons | | Wolves | |
| April | 1, 2005 | Heat | | Pistons | |
| April | 3, 2005 | Hawks | | Pistons | |
| April | 4, 2005 | Bulls | | Pistons | |
| April | 5, 2005 | Hawks | | Pistons | |
| April | 6, 2005 | Pistons | | Sonics | |
| April | 7, 2005 | Raptors | | Pistons | |
| April | 9, 2005 | Pistons | | Blazers | |
| April | 10, 2005 | Pistons | | Kings | |
| April | 11, 2005 | Nuggets | | Pistons | |
| April | 13, 2005 | Pistons | | Mavericks | |
| April | 14, 2005 | Pistons | | Pacers | |
| April | 17, 2005 | Pistons | | Bucks | |
| April | 20, 2005 | Rockets | | Pistons | |
| April | 22, 2005 | Nets | | Pistons | |
| April | 25, 2005 | Wizards | | Pistons | |
| April | 27, 2005 | Cavaliers | | Pistons | |
| April | 29, 2005 | Celtics | | Pistons | |
| May | 4, 2005 | Pistons | | Warriors | |